Daily Bolus of LR: Flumazenil

Leave a comment

March 8, 2012 by dailybolusoflr

  • Competitive antagonist of benzodiazepines
  • Dose 0.1mg-0.2mg IV every 1-2 minutes until desired effect
  • Clinical effects last 30-60 minutes and so recurrent sedation can be seen with longer acting benzodiazepines
  • Use should be primarily considered for reversal of procedural sedation and not for use in patients who may be benzodiazepine dependent and present in overdose
  • Sudden withdrawal can be associated with seizures in patients who are dependent
  • Note: A case report notes use of flumazenil to reverse acute delirium in an elderly patient treated with lorazepam for sedation       
J Emerg Med. 2003 Feb;24(2):181-3.
Ref: Harwood Nuss. 5th ed

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

%d bloggers like this: