Daily Bolus of LR: Flumazenil
Leave a commentMarch 8, 2012 by dailybolusoflr
Flumazenil
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Competitive antagonist of benzodiazepines
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Dose 0.1mg-0.2mg IV every 1-2 minutes until desired effect
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Clinical effects last 30-60 minutes and so recurrent sedation can be seen with longer acting benzodiazepines
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Use should be primarily considered for reversal of procedural sedation and not for use in patients who may be benzodiazepine dependent and present in overdose
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Sudden withdrawal can be associated with seizures in patients who are dependent
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Note: A case report notes use of flumazenil to reverse acute delirium in an elderly patient treated with lorazepam for sedation
J Emerg Med. 2003 Feb;24(2):181-3.
Ref: Harwood Nuss. 5th ed
Category: Pharmacology, Toxic/Metabolic
