Daily Bolus of LR: Flumazenil

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March 8, 2012 by dailybolusoflr

Flumazenil
  • Competitive antagonist of benzodiazepines
  • Dose 0.1mg-0.2mg IV every 1-2 minutes until desired effect
  • Clinical effects last 30-60 minutes and so recurrent sedation can be seen with longer acting benzodiazepines
  • Use should be primarily considered for reversal of procedural sedation and not for use in patients who may be benzodiazepine dependent and present in overdose
  • Sudden withdrawal can be associated with seizures in patients who are dependent
  • Note: A case report notes use of flumazenil to reverse acute delirium in an elderly patient treated with lorazepam for sedation       
J Emerg Med. 2003 Feb;24(2):181-3.
Ref: Harwood Nuss. 5th ed

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