October 6, 2011 by dailybolusoflr
Use of progesterone in the diagnosis of ectopic pregnancy- not as helpful as you would hope!
· Progesterone as a diagnostic test for the identification of ectopic pregnancy is unfortunately not as useful as one would hope
· Serum levels of progesterone in the first trimester stay relatively consistent and do not increase with gestational age.
· A progesterone level over 20-25ng/mL is predictive (>95%) of a normal pregnancy
· A progesterone level under 5mg/mL is predictive ( approaching 100%) of an abnormal pregnancy
· Abnormal pregnancy cannot be distinguished between ectopic versus abnormal IUP
· A significant majority of patients will have levels in the indeterminate range (5-20) and thus this test does not offer any significant assistance in diagnosis when it is in this range
Ref: Am Fam Physician. 2007 Feb 1;75(3):312. and Emerg Med Clin N Am21 (2003) 565–584