Daily Bolus of LR: Dosing of FFP

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March 8, 2011 by dailybolusoflr

FFP or fresh frozen plasma is a blood component which contains all clotting factors.

Its main indication for use is in patients on warfarin who have active bleeding or who require an invasive procedure.

The typical dosing for FFP is weight based and ranges from 5-10 cc/kg (although some sources state up to 15 cc/kg). This has been determined to raise the clotting factors to about 30% of physiologic activity.

To order FFP:
-remember most institutions have FFP in 250 cc bags
-thus, when you know how many total cc's you need, you can calculate how many “units.”

For example, a 70 kg man would need between 350 cc and 700 cc of FFP. The correct dosing would be 2-3 units, which would be between 500-750 cc of FFP.


Linda Regan, MD FACEP
Program Director, Emergency Medicine Residency
Johns Hopkins Medical Institutions

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